Another preprint from the lab. This is Midori Ishii’s work on two protein kinases KKT10 and KKT19 in Trypanosoma brucei. This organism lacks a canonical spindle checkpoint system and it was not known whether there is any regulatory mechanism for mitotic progression control. We found that these protein kinases play a key role in promoting mitotic progression.
Ishii M and Akiyoshi B (2019) Unconventional kinetochore kinases KKT10/19 promote the metaphase to anaphase transition in Trypanosoma brucei. bioRxiv (https://www.biorxiv.org/content/10.1101/806224v1)